Variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population

Wenqi Xu; Jiayi Liu; Peilin Yu; Xiaofei Shi; Rongzeng Liu

doi:10.1080/07853890.2026.2622737

January 30, 2026Annals of MedicineOpen Access

Variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population

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Key Points

The aim is to examine the relationship between IRF5 gene variants and susceptibility to systemic lupus erythematosus (SLE).
Analysis of genetic variants in the IRF5 gene
Assessment of SLE susceptibility in a Han Chinese population
Evaluation of biomarkers for SLE risk
IRF5 gene variants significantly increase susceptibility to SLE
Variants could serve as biomarkers for SLE risk assessment
Study provides insights into the pathogenesis of SLE

Implication

Genetic variants in IRF5 influence systemic lupus erythematosus risk in Han Chinese, indicating potential biomarkers for disease evaluation.

Abstract

These findings indicate that IRF5 gene variants substantially modulate susceptibility to SLE in the Han Chinese population. They hold potential as biomarkers for evaluating SLE risk and offer valuable perspectives into disease pathogenesis.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6980fefbc1c9540dea811918 https://doi.org/10.1080/07853890.2026.2622737

View Full Paper

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Variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population

Key Points

Implication

Abstract

Discussion

Cite This Study

Variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population

Key Points

Implication

Abstract

Discussion

Cite This Study

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