Key result
IRF5 polymorphisms, including CGGGGindel (OR 1.38) and rs2004640 (OR 1.36), were significantly associated with an increased risk of rheumatoid arthritis in a Korean population.
Why the study?
Are IRF5 polymorphisms associated with an increased risk of rheumatoid arthritis in a Korean population?
Population
2183 subjects (1204 rheumatoid arthritis cases and 979 controls) in a Korean population
Comparison
IRF5 polymorphisms vs Controls without rheumatoid arthritis
Design
Case-control
Authors
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Supports IRF5 as RA susceptibility locus in Koreans; leaves open clinical utility pending replication and functional studies.
Case-Control (n=2,183)
Are IRF5 polymorphisms associated with an increased risk of rheumatoid arthritis in a Korean population?
Odds Ratio: 1.38 (95% CI 1.09–1.76)
p-value: p=0.04
IRF5 polymorphisms are associated with genetic susceptibility to rheumatoid arthritis in the Korean population, particularly in SE-positive or anti-CCP antibody-positive patients.
Kim et al. (2008) conducted a case-control in Rheumatoid Arthritis (n=2,183). IRF5 polymorphisms vs. Healthy controls was evaluated on Risk of rheumatoid arthritis (CGGGGindel polymorphism) (OR 1.38, 95% CI 1.09-1.76, p=0.04). IRF5 polymorphisms, including CGGGGindel (OR 1.38) and rs2004640 (OR 1.36), were significantly associated with an increased risk of rheumatoid arthritis in a Korean population.
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