What question did this study set out to answer?

To examine how dietary polyphenols, especially flavonoids, can reduce oxidative stress and inflammation related to various diseases.

February 2, 2026International Journal of Molecular SciencesOpen Access

Dietary Polyphenols (Flavonoids) Derived from Plants for Use in Therapeutic Health: Antioxidant Performance, ROS, Molecular Mechanisms, and Bioavailability Limitations

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Authors

TBTomás Gabriel BasUniversidad Católica del Norte

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Implication

This analysis reveals how plant-derived polyphenols combat oxidative stress in therapeutic health, suggesting important implications for future interventions.

Key Points

To examine how dietary polyphenols, especially flavonoids, can reduce oxidative stress and inflammation related to various diseases.
Analyzed direct antioxidant mechanisms including radical scavenging and metal chelation.
Explored redox signaling pathways such as Keap1–Nrf2/ARE.
Reviewed evidence from in vitro, in vivo, and human studies to assess limitations and context dependencies.
Identified clinically relevant endpoints and dietary sources for polyphenols.
Documented roles of polyphenols in reducing oxidative stress and inflammation linked to cardiovascular and neurodegenerative diseases.
Highlighted the importance of bioavailability and microbiota in determining the effectiveness of flavonoids.
Outlined both supported and preliminary evidence for cardiovascular, cognitive, and immunometabolic benefits.

Cite This Study

Tomás Gabriel Bas (2026) studied this question.

synapsesocial.com/papers/6980ff08c1c9540dea811a5a https://doi.org/10.3390/ijms27031404

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Implication

This analysis reveals how plant-derived polyphenols combat oxidative stress in therapeutic health, suggesting important implications for future interventions.

Dietary Polyphenols (Flavonoids) Derived from Plants for Use in Therapeutic Health: Antioxidant Performance, ROS, Molecular Mechanisms, and Bioavailability Limitations

Discussion

Member takes

Implication

Key Points

Cite This Study

Dietary Polyphenols (Flavonoids) Derived from Plants for Use in Therapeutic Health: Antioxidant Performance, ROS, Molecular Mechanisms, and Bioavailability Limitations

Discussion

Member takes

Implication

Key Points

Cite This Study

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