Key result
Right ventricular free wall strain (AUC 0.71; 95% CI 0.62-0.80) and end-diastolic area were independently associated with severe symptoms in patients with pulmonary arterial hypertension.
Why the study?
Although various echocardiographic indices assess right ventricular size and function in pulmonary arterial hypertension, a comprehensive analysis of their association with functional class was lacking.
Which right ventricular echocardiographic parameters are most strongly associated with severe symptoms (WHO functional class III/IV) in patients with pulmonary arterial hypertension?
Observational (n=108)
No
Which right ventricular echocardiographic parameters are most strongly associated with severe symptoms (WHO functional class III/IV) in patients with pulmonary arterial hypertension?
In patients with PAH, right ventricular free wall strain and end-diastolic area are stronger echocardiographic indicators of symptom severity than other standard RV indices.
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Škafar et al. (2026) conducted an observational in Pulmonary arterial hypertension (PAH) (n=108). Right ventricular free wall strain (RVFWS) and end-diastolic area (RVEDa) vs. Other echocardiographic indices was evaluated on Severe symptoms (WHO functional class III or IV) (AUC 0.71, 95% CI 0.62-0.80, p=<0.005). Right ventricular free wall strain (AUC 0.71; 95% CI 0.62-0.80) and end-diastolic area were independently associated with severe symptoms in patients with pulmonary arterial hypertension.
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