This dual-catalytic strategy demonstrates effective cross-coupling of alkyl bromides and difluoromethylborates, suggesting broad application potential.
A copper/photoredox dual-catalytic strategy has been developed for radical-radical C(sp³)-CF₂H cross-coupling between alkyl bromides and readily accessible tetracoordinated difluoromethylborates. In this protocol, visible-light-induced single-electron oxidation of the borates generates difluoromethyl radicals (•CF₂H), which are subsequently intercepted by a copper catalyst to forge C(sp³)-CF₂H bonds. This redox-neutral approach proceeds without the need for stoichiometric halogen atom transfer (XAT) reagents, oxidants, or reductants, exhibits broad functional group tolerance, and enables late-stage installation of the pharmaceutically privileged CF₂H motif into aliphatic frameworks.
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Cao et al. (2026) studied this question.
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