Research reveals lipid-lowering effects of esterified seco-polycyclic compounds from two Hypericum species, suggesting therapeutic potential.
Hyperesternoids A-K (1-11, respectively), 11 unique esterified seco-PPAPs (seco-polycyclic polyprenylated acylphloroglucinols) with three types of scaffold systems, 5/6 bicyclic (1-3), 5/7/6 tricyclic (4-6), and 5/6/6 tricyclic (7-11), were isolated from two plants of the Hypericum genus. Notably, crystalline mate and chemical transformation methods provided several practical strategies for the elucidation of seco-PPAPs with complex and variable structures. Biologically, the PPARα agonistic activities of all isolates were evaluated via the dual-luciferase reporter assay, and their lipid-lowering effects were studied.
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Dong et al. (2026) studied this question.
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