Evaluating Patients with Olfactory Dysfunction after COVID-19 Infection by Questionnaire of Olfactory Disorders-Negative Statements

Background: The number of patients with COVID-19-induced olfactory dysfunction has consistently increased since the onset of the pandemic. Since a considerable proportion of these patients have olfactory dysfunction for a relatively long period of time, their quality of life (QOL) may considerably be impacted as a result. Aim: The aim of the present study was to investigate the adverse effects of olfactory dysfunction on QOL in patients with COVID-19-induced hyposmia or anosmia. Methods: The data were obtained via self-reported online questionnaire in individuals who met the inclusion criteria. The questionnaire included demographics, olfactory status and Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS). Results: Among1531 participants, 1072 individuals met the inclusion criteria, with 588 (54.85%) having hyposmia and 484 (45.15%) anosmia. Average age was 35.7 in the hyposmic group and 34.5 in the anosmic group. Concurrent hypogeusia/ageusia was reported in 398 (67.7%) of cases with hyposmia and in 346 (71.5%) of participants with anosmia. Lack of enjoyment of eating food was the most negative effect in both hyposmic and anosmic groups, followed by annoyance when eating food and a continuous awareness of the olfactory problem. The mean QOD-NS score was 20.5±10.2 in the hyposmic group and 23.3±10.4 in the anosmic group, demonstrating significant adverse impact on QOL. Conclusion: Persistent olfactory dysfunction in patients with COVID-19 has adverse effects on QOL. Early diagnosis and treatment of olfactory dysfunction may be crucial in limiting the adverse impact on QOL by psychological and nutritional support and olfactory rehabilitation.