Key result
Drug overdose suicide attempts link to elevated CRP and inflammatory indices, particularly CAR.
Why the study?
The relationship between psychiatric disorders and systemic inflammation remains incompletely understood, with increasing evidence suggesting inflammatory processes may contribute to biological mechanisms underlying suicidal behavior.
Are hemogram-derived inflammatory indices associated with suicide attempts by oral drug overdose?
Population
343 patients hospitalized following a suicide attempt by oral medication overdose and 421 age- and sex-matched healthy individuals
Comparison
Patients hospitalized following suicide attempt by drug overdose vs healthy individuals
Design
Retrospective observational comparative study
Authors
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Elevated CAR in overdose attempters should not yet change practice; leaves open its value for prospective risk prediction.
Observational (n=764)
Are hemogram-derived inflammatory indices associated with suicide attempts by oral drug overdose?
Hemogram-derived inflammatory indices, particularly the CRP-to-albumin ratio, are significantly elevated in patients who attempted suicide by drug overdose, suggesting a potential role as biomarkers for suicide risk assessment.
Bas et al. (2026) conducted an observational in Suicide attempt by oral drug overdose (n=764). Suicide attempt by oral drug overdose vs. Healthy individuals was evaluated on Classical inflammatory markers and hemogram-derived inflammatory indices. Suicide attempts by oral drug overdose were associated with significantly elevated inflammatory markers and indices, particularly the CRP-to-albumin ratio, compared to healthy controls.
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