Background Multiple Family Group Therapy (MFGT) shows promise for improving outcomes among adolescents living with HIV (ALHIV), but strategies for successful implementation and positive outcomes in resource‐constrained settings remain unexplored. This study explored multistakeholder perspectives on effective strategies to support the implementation of the MFGT in Ghana. Methods A qualitative descriptive study was conducted at a district hospital in the Lower Manya Krobo District, Ghana. Data were collected through focus group discussions with ALHIV ( n = 12), caregivers ( n = 13), and health professionals ( n = 5), supplemented by three in‐depth interviews (with ALHIV). All stakeholder groups were recruited purposively with assistance from health workers. Data were analyzed using contextual thematic analysis guided by the Consolidated Framework for Implementation Research. Results Five themes emerged: (1) incentives and motivation for participants and healthcare workers, including transportation support and fair compensation; (2) skills building and capacity development through multimodal training approaches; (3) program design elements focusing on creating a sense of belonging through program identifiers and clear expectations; (4) addressing attendance barriers through flexible scheduling and reminder systems; and (5) program delivery optimization via diversified facilitation, adolescent engagement, and preprogram disclosure support. Conclusions Successful MFGT implementation requires comprehensive strategies that address the needs of multiple stakeholders across individual, organizational, and contextual levels. The findings provide evidence‐based implementation strategies that balance intervention fidelity with contextual adaptation for family‐based HIV interventions in resource‐constrained settings.
Boakye et al. (2026) studied this question.