Key result
Elevated METS-IR is linked to ~11% higher risk of vascular cognitive impairment after minor stroke.
Case-Control (n=236)
No
Answers are grounded in this paper and cite their sources.
Observational analysis reveals cognitive impairment links with insulin resistance in NICE patients, suggesting inflammation as a target for intervention.
Cognitive impairment in NICE patients is strongly associated with elevated insulin resistance and chronic inflammation. METS-IR exhibits a linear negative association with cognitive function, serving as an independent risk predictor. The constructed nomogram provides a reliable tool for early VCI detection with robust discrimination and calibration. Notably, SII partially mediates the association between METS-IR and cognition, highlighting inflammatory pathways as a candidate target for future interventional studies.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2026) conducted a case-control in Non-disabling ischemic cerebrovascular events (NICE) (n=236). Metabolic score for insulin resistance (METS-IR) vs. Normal cognitive function (NCF) was evaluated on Vascular cognitive impairment (MoCA score <= 24 and Hachinski Ischemic Scale score > 7) (OR 1.11, 95% CI 1.06-1.17). Elevated METS-IR was independently associated with increased risk of vascular cognitive impairment (OR 1.11, 95% CI 1.06-1.17) in patients with non-disabling ischemic cerebrovascular events.
Synapse has enriched 10 related papers. Consider them for comparative context: