Metastatic meningioma in childhood and adolescence

Metastatic meningioma in childhood and adolescence is an extremely rare entity, with limited available data. We sought to characterize features, treatment and outcomes by performing a systematic review of all cases of metastatic meningioma diagnosed before 18 years of age published since 1989. We found metastases predominantly occurred in patients with grade 2 and 3 tumors and at time of relapse. Most metastatic sites were extracranial, with lung/pleura the dominant extracranial site. The remainder occurred at distant sites within the central nervous system. We propose that screening of these sites should be considered if relapse is suspected.