What question did this study set out to answer?

To measure the intensity and distribution of purifying selection across mammalian genomes using comparative sequence analysis and identify functional genomic elements.

June 17, 2005Genome ResearchOpen Access

Distribution and intensity of constraint in mammalian genomic sequence

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To measure the intensity and distribution of purifying selection across mammalian genomes using comparative sequence analysis and identify functional genomic elements.
Aligned orthologous genomic DNA sequences across 29 mammalian species, capturing approximately 3.9 neutral substitutions per site across roughly 1.9 Mbp of the human genome.
Applied Genomic Evolutionary Rate Profiling (GERP) to quantify deficits in nucleotide substitution as rejected substitutions at high resolution.
Constrained elements spanning 3 bp to over 1 kbp covered approximately 5.5% of the human locus evaluated.
Total nonexonic constraint within the locus was estimated to be roughly twice that observed for exonic constraint.
Constrained elements clustered into functional regions and overlapped ancestral repeats, showing that highly constrained elements are more numerous than previously appreciated.

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Implication

Comparative genomic analysis reveals substantial nonexonic evolutionary constraint across 29 mammalian species, indicating that functional elements outside coding genes are widely conserved.

Cite This Study

Cooper et al. (2005) studied this question.

synapsesocial.com/papers/69835a64a55a3e57bf87ffdb https://doi.org/10.1101/gr.3577405

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Implication

Comparative genomic analysis reveals substantial nonexonic evolutionary constraint across 29 mammalian species, indicating that functional elements outside coding genes are widely conserved.

Distribution and intensity of constraint in mammalian genomic sequence

Key Points

Discussion

Implication

Cite This Study

Distribution and intensity of constraint in mammalian genomic sequence

Key Points

Discussion

Implication

Cite This Study

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