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February 5, 2026Clinica Chimica Acta2 citationsOpen Access

Comparison of manual with artificial intelligence-aided interpretation of ANA HEp-2 IIF assay patterns in a clinical diagnostics lab

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JSJonas SchmidtSWSarina WeißFBFrithjof Blessing

Key Points

  • This research aims to evaluate the performance of AI software versus human observers in interpreting ANA HEp-2 IIF assay patterns.
  • Comparative analysis of manual interpretation and AI-aided interpretation.
  • Evaluation conducted in a clinical diagnostics lab.
  • Assessment of AI performance against human accuracy in image analysis.
  • AI software demonstrates performance on par with human observers.
  • Use of AI reduces subjectivity in image classification.
  • AI aids in streamlining the diagnostic workflow for ANA IIF assays.

Abstract

The AI-based software showed a similar performance compared to human observers. AI-aided ANA image analysis can facilitate the diagnostic workflow of ANA IIF assays and reduce subjectivity during image classification.

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Cite This Study

Schmidt et al. (2026) studied this question.

synapsesocial.com/papers/69843360f1d9ada3c1fb06c8https://doi.org/10.1016/j.cca.2026.120881
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