Isopsoralen alleviates osteoarthritis by modulating the MAPK/NF-κB signaling pathway and regulating the structure of gut microbiota.

Aoyu Zhang; Shuying Li; Jie Qiao; Chuanqi Zhong; Zhiwen Zhang; Xiguang Ye; Jun Jin; Shiyan Shang; Song Wu; Qing Zhang; Gongxu Yang

doi:10.1016/j.jep.2026.121257

January 1, 2026Journal of EthnopharmacologyOpen Access

Isopsoralen alleviates osteoarthritis by modulating the MAPK/NF-κB signaling pathway and regulating the structure of gut microbiota.

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Key Points

The aim is to investigate how isopsoralen affects osteoarthritis through gut microbiota modulation and MAPK/NF-kB pathway inhibition.
Examined the effects of isopsoralen on osteoarthritis.
Analyzed changes in gut microbiota composition.
Assessed inflammation markers and bone structure in treated models.
Isopsoralen significantly reduced inflammation associated with osteoarthritis.
The treatment improved bone structure abnormalities.
No signs of hepatorenal toxicity were observed during treatment.

Implication

Demonstrates how isopsoralen alleviates osteoarthritis by regulating gut microbiota and reducing inflammation.

Abstract

ISO alleviates OA by modulating gut microbiota/SCFAs and inhibiting the MAPK/NF-κB pathway, thereby reducing inflammation and improving bone abnormalities, without hepatorenal toxicity.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69843360f1d9ada3c1fb0741 https://doi.org/10.1016/j.jep.2026.121257

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Isopsoralen alleviates osteoarthritis by modulating the MAPK/NF-κB signaling pathway and regulating the structure of gut microbiota.

Key Points

Implication

Abstract

Discussion

Cite This Study

Isopsoralen alleviates osteoarthritis by modulating the MAPK/NF-κB signaling pathway and regulating the structure of gut microbiota.

Key Points

Implication

Abstract

Discussion

Cite This Study

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