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February 5, 2026Neoplasia2 citationsOpen Access

The Role of CCR1 as a decisive factor for immune response activation versus suppression phenotypes in gastric cancer

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KSKeran SunJNJingyuan NingKJKeqi Jia

Key Points

  • This research investigates how CCR1 affects immune response phenotypes in gastric cancer.
  • Examined the role of CCR1 in modulating T cell distribution
  • Analyzed interactions with chemokines CXCL9 and CXCL10
  • CCR1 significantly influences T cell distribution patterns
  • Findings suggest CCR1 could be targeted for therapeutic interventions in gastric cancer.

Abstract

CCR1 modulates T cell distribution via CXCL9/CXCL10, suggesting potential therapeutic directions.

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Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69843360f1d9ada3c1fb077chttps://doi.org/10.1016/j.neo.2026.101277
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 7479: A CCL20-high chemokine program defines a CCR6+ immune-myeloid niche in gastric cancer2026
  2. 2CCR10: a comprehensive review of its function, phylogeny, role in immune cell trafficking and disease pathogenesis2025
  3. 3CCR5 expression and conformational stability as potential cooperative modulators of immune phenotypes and therapy response in breast cancer2025
  4. 4CCR5 and CCL5 in metastatic colorectal cancer2024 · 12 citations
  5. 5The CXCL9–CXCR3 Axis Mediates Tumor Progression and Immune Checkpoint Regulation in Colorectal Cancer2026