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February 5, 2026BMC Cancer2 citationsOpen Access

Longitudinal plasma proteome profiling identifies IFN-gamma dynamics as a time-dependent predictor of immunotherapy response in advanced gastric cancer

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JFJingshuai FangYYYuhui YuYSYan Sun

Key Points

  • The research aims to identify biomarkers that predict response to immunotherapy in advanced gastric cancer, focusing on IFN-gamma dynamics.
  • Longitudinal plasma proteome profiling was conducted.
  • Assessment of IFN-gamma levels and PD-L1 Combined Positive Score (CPS) was performed.
  • Data analysis focused on predictive efficacy of the composite model.
  • IFN-gamma was found to be a critical biomarker for assessing prognosis.
  • The combination of IFN-gamma and PD-L1 CPS showed greater predictive ability than either alone.
  • Study indicates that further validation of additional biomarkers is necessary.

Abstract

IFN-gamma emerges as a critical biomarker for prognostic assessment and therapeutic monitoring in advanced GC immunotherapy, and its composite model incorporating PD-L1 Combined Positive Score (CPS) demonstrated superior predictive efficacy, highlighting the necessity for validating additional biomarkers in future clinical studies.

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Cite This Study

Fang et al. (2026) studied this question.

synapsesocial.com/papers/69843383f1d9ada3c1fb0ad5https://doi.org/10.1186/s12885-026-15623-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic Integrative Immune Profiling Reveals Early Biomarkers of Response and Prognosis in Advanced Gastric Cancer Treated with Nivolumab Plus Chemotherapy2025
  2. 2Proteomic profiling and biomarker discovery for predicting the response to PD-1 inhibitor immunotherapy in gastric cancer patients2024 · 5 citations
  3. 3Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer2024 · 1 citations
  4. 4Plasma proteomics-based liquid biopsy for predicting efficacy of PD-1-based immunochemotherapy in advanced gastric cancer: a prospective cohort study2026
  5. 5Rethinking biomarker strategy in gastric cancer immunotherapy: from tumor to host2026 · 2 citations