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February 5, 2026Frontiers in Cardiovascular MedicineOpen Access

Limited performance questions retrospective use of quantitative flow ratio in coronary artery bypass grafting

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Authors

HAHannes AbfaltererDJDominik JankerInnsbruck Medical UniversityLRLorenz RüfInnsbruck Medical University

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Implication

Retrospective analysis assesses graft patency in patients using quantitative flow ratio, suggesting caution in its use.

Key Points

  • Evaluate the association of quantitative flow ratio (QFR) with arterial graft patency in patients post-coronary artery bypass grafting.
  • Retrospective investigation of patients with isolated coronary artery bypass grafting and postoperative reassessment.
  • Analysis of preoperative angiography to assess QFR of target vessels for arterial grafts.
  • Blinded assessment by certified investigators regarding postoperative graft patency.
  • Kaplan-Meier and Cox regression analyses conducted to evaluate graft patency rates.
  • Higher graft patency rates were found for grafts with QFR values ≤0.80 (log-rank: p = 0.017).
  • QFR ≤ 0.80 was identified as an independent predictor for graft patency (HR: 0.475, p = 0.015).
  • Most target vessels (80.22%) were not analyzable due to retrospective constraints.
  • Overall diagnostic performance of the QFR assessment was poor (AUC: 0.595).

Cite This Study

Abfalterer et al. (2026) studied this question.

synapsesocial.com/papers/69843398f1d9ada3c1fb0cffhttps://doi.org/10.3389/fcvm.2026.1757011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic Agreement of Quantitative Flow Ratio With Fractional Flow Reserve and Instantaneous Wave‐Free Ratio2019 · 71 citations
  2. 2Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention2009 · 4,288 citations
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  5. 5Potential of quantitative flow ratio in guiding conduit selection between radial artery and saphenous vein graft for coronary artery bypass grafting2025 · 4 citations