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February 5, 2026MedCommOpen Access

Organ‐on‐a‐Chip Technology and Global Multi‐Omics: Current Applications and Future Directions

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Authors

XCXuxia CaoCXCongmin XiaCLCaifeng Li

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Overview

This review explores how multi-omics integration enhances organ-on-a-chip models, signaling new avenues for personalized medicine.

Key Points

  • The research aims to examine the integration of organ-on-a-chip technology with multi-omics for improved biomedical modeling.
  • Systematic review of organ-on-a-chip platform development from 2D to 3D systems.
  • Analysis of mechanistic insights gained through multi-omics integration.
  • Evaluation of challenges in standardization and clinical translation of OoC technology.
  • Proposal for a development roadmap for next-generation disease models.
  • Demonstrated enhancement of physiological relevance in OoC platforms through 3D microenvironments.
  • Revealed molecular mechanisms in disease modeling using combined multi-omics techniques.
  • Identified key challenges in standardization and translation into clinical applications.
  • Outlined strategic guidance for future development in standardized organ-on-a-chip systems.

Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/69843398f1d9ada3c1fb0d2bhttps://doi.org/10.1002/mco2.70603
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