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July 8, 2026Biotechnology and Bioengineering

Bridging Organ‐on‐a‐Chip and Omics: A Multi‐Dimensional Frontier in Biomedical Research

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Authors

ZCZhaoming ChengCZChuanjun ZhangXLXuwen Li

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Overview

Review highlights the integration of organ-on-a-chip technology and omics in advancing precision medicine, addressing challenges.

Key Points

  • This review aims to explore the integration of organ-on-a-chip (OOC) technology with omics methodologies to enhance biomedical research.
  • Systematic examination of organ-on-a-chip systems and their engineering principles.
  • Analysis of key omics domains: genomics, transcriptomics, proteomics, and metabolomics.
  • Discussion on the multi-dimensional applications of integrated OOC and omics technologies.
  • Present high-resolution analyses of drug metabolism and disease mechanisms using OOC and omics integration.
  • Identify challenges, such as developing whole-organ mimetics and real-time data integration with AI.
  • Highlight the potential for improved environmental toxicity assessments and host-microbiome studies through this integration.

Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/6a4dea63d2ea289ef628411ehttps://doi.org/10.1002/bit.70280
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