Construction of oxindole spiro medium-sized S-heterocycles via ring expansion [2,3]-sigmatropic rearrangement

Yongqiang Xu; Wenkai Li; Xiaoli Gu; Yuhan Zhou; Jingping Qu; Baomin Wang

doi:10.1039/d5cc06578j

January 1, 2026Chemical Communications

Construction of oxindole spiro medium-sized S-heterocycles via ring expansion [2,3]-sigmatropic rearrangement

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Key Points

This research aims to develop a strategy for synthesizing medium-sized S-heterocycles using oxindole precursors.
Utilized ring expansion techniques
Employed [2,3]-sigmatropic rearrangement
Focused on synthesizing oxindole-spiro compounds
Successfully constructed oxindole-annulated medium-sized S-heterocycles
Demonstrated efficiency in synthetic strategy
Showed potential applications in bioactive molecule development

Implication

Demonstrates a new method to synthesize S-heterocycles, highlighting its potential for bioactive compounds.

Abstract

The significance of medium-sized rings is demonstrated by their being key structural cores in diverse bioactive molecules. Herein, we describe an efficient strategy for synthesizing oxindole-annulated medium-sized S-heterocycles via ring...

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69843398f1d9ada3c1fb0d41 https://doi.org/10.1039/d5cc06578j

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Construction of oxindole spiro medium-sized S-heterocycles via ring expansion [2,3]-sigmatropic rearrangement

Key Points

Implication

Abstract

Discussion

Cite This Study

Construction of oxindole spiro medium-sized S-heterocycles via ring expansion [2,3]-sigmatropic rearrangement

Key Points

Implication

Abstract

Discussion

Cite This Study

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