Comprehensive Evaluation of a Cream With Advanced Soothing Complex for Skin Recovery Following Intense Pulsed Light Therapy

Background Intense pulsed light (IPL) therapy is widely used for skin rejuvenation but frequently induces transient skin barrier impairment, erythema, and discomfort. Post‐procedure skincare targeting barrier repair and symptom relief remains a clinical priority. Objective To evaluate the efficacy, safety, and satisfaction of a cream containing 4‐tert‐butylcyclohexanol, Tephrosia purpurea seed extract, and Schisandra sphenanthera extract (TTS cream) in facilitating skin recovery after IPL therapy. Methods In this randomized, double‐blind, split‐face study, 30 healthy female subjects received IPL therapy. One hemiface was randomly applied TTS cream, and the contralateral side was applied a control moisturizing toner after IPL. Objective instrument assessments were conducted at baseline (D0), post‐IPL (D0′), 30 min post‐application (D30min), and on days 3 (D3), 7 (D7), 14 (D14), and 28 (D28). Subjective assessments and satisfaction surveys were concurrently collected. Results IPL therapy significantly increased TEWL, erythema, and skin dehydration at D0′ ( p < 0.01). At D30min, compared to the control, TTS cream significantly improved skin hydration (∆ = 12.79 vs. 0.32 C.U., p < 0.01). At D28, TTS cream significantly reduced erythema index (∆ = −54.61, p < 0.01), erythema area (∆ = −7.02%, p < 0.01), and TEWL (∆ = −4.41 g/m 2 h, p < 0.01). Subjective assessments confirmed TTS cream significantly alleviated stinging, burning, and redness ( p < 0.01). Satisfaction rates reached 100% for gentleness and 96.67% for symptom relief. No adverse effects were reported throughout the study. Conclusions These findings indicate that the TTS cream effectively enhances skin barrier recovery, reduces erythema, and relieves discomfort following IPL therapy, highlighting its potential application in the postoperative care of aesthetic medicine.