Aryne-Mediated Synthesis of Sterically Hindered Arylamines Using TEMPO as the Amine Source

Qiaofeng Liang; Zhiwen Zhong; Zhihan Sheng; Chenlong Zhu; Bingfeng Sun

doi:10.1039/d5ob01872b

January 1, 2025Organic & Biomolecular Chemistry

Aryne-Mediated Synthesis of Sterically Hindered Arylamines Using TEMPO as the Amine Source

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Key Points

The aim is to demonstrate an efficient synthesis of sterically hindered arylamines using TEMPO as an amine source.
Utilized aryne-mediated reactions
Used TEMPO for amine source
Conducted mechanistic studies to investigate reactions
Successfully synthesized sterically hindered arylamines
Mechanistic studies suggest a significant interaction between TEMPO and aryne

Implication

Mechanistic study reveals synthetic approach for arylamines using TEMPO, indicating efficiency in synthesis.

Abstract

Herein, an aryne-mediated synthesis of sterically hindered arylamines using 2,2,6,6-tetramethylpiperidoxyl (TEMPO) as the amine source is reported. Mechanistic studies suggest that TEMPO might adds to the aryne to form an...

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Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/69843398f1d9ada3c1fb0e3c https://doi.org/10.1039/d5ob01872b

View Full Paper

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Aryne-Mediated Synthesis of Sterically Hindered Arylamines Using TEMPO as the Amine Source

Key Points

Implication

Abstract

Discussion

Cite This Study

Aryne-Mediated Synthesis of Sterically Hindered Arylamines Using TEMPO as the Amine Source

Key Points

Implication

Abstract

Discussion

Cite This Study

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