What question did this study set out to answer?

Assess the occurrence of peri-ictal MRI abnormalities in patients with status epilepticus and ictal-interictal continuum, and explore their relationship through latent cluster analysis.

February 5, 2026EpilepsiaOpen Access

Ictal–interictal continuum and status epilepticus: Two sides of the same coin? A prospective magnetic resonance imaging study

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Assess the occurrence of peri-ictal MRI abnormalities in patients with status epilepticus and ictal-interictal continuum, and explore their relationship through latent cluster analysis.
Conducted a prospective cohort study with 223 adult patients diagnosed with SE or IIC.
Performed electroencephalography and MRI within 48 hours of diagnosis.
Stratified individuals into IIC and SE groups.
Assessed MRI abnormalities using various imaging sequences.
Applied latent cluster analysis to identify classes based on EEG patterns and etiology.
PMA occurred similarly in the IIC group (47%) compared to the SE group (43%).
Peri-ictal hyperperfusion was linked to lower frequency PD/SW in 63% of IIC patients.
Latent cluster analysis revealed two classes with varied frequencies of PMA, indicating different underlying causes.

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Implication

Prospective study investigates MRI abnormalities in status epilepticus and ictal-interictal continuum, suggesting diagnostic overlaps.

Cite This Study

Bosque‐Varela et al. (2026) studied this question.

synapsesocial.com/papers/698433d8f1d9ada3c1fb144a https://doi.org/10.1002/epi.70131

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Ictal–interictal continuum and status epilepticus: Two sides of the same coin? A prospective magnetic resonance imaging study

Key Points

Discussion

Implication

Cite This Study

Ictal–interictal continuum and status epilepticus: Two sides of the same coin? A prospective magnetic resonance imaging study

Key Points

Discussion

Implication

Cite This Study

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