In moderate to severe chronic breathlessness, low-dose, long-acting oral morphine did not improve worst breathlessness at 28 d

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To evaluate if low-dose, long-acting oral morphine can reduce worst breathlessness over 28 days in individuals with chronic breathlessness.
Participants with moderate to severe chronic breathlessness were treated with low-dose oral morphine.
Breathlessness levels were assessed at the start and after 28 days of treatment.
Simultaneous monitoring of other symptoms and side effects was conducted.
No significant improvement was observed in worst breathlessness scores after 28 days of treatment with morphine.
Patients reported similar levels of breathlessness compared to those not receiving morphine treatment.
Side effects were noted but did not correlate with significant symptom relief.

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Findings show low-dose morphine did not improve breathlessness in individuals with chronic conditions, suggesting a need for alternative treatments.

GIM/FP/GP: [Formula: see text] Pulmonology: [Formula: see text].

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Guy W. Soo Hoo (2026) studied this question.

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