Why the study?
Does 20 mg daily oral modified release morphine reduce the severity of breathlessness in patients with HFrEF?
Does 20 mg daily oral modified release morphine reduce the severity of breathlessness in patients with HFrEF?
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An underpowered trial of oral modified release morphine failed to show a significant reduction in breathlessness in HFrEF patients, highlighting the need for better-designed, physiologically focused symptom-relief trials.
Andrew J.S. Coats (2019) studied this question.
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