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This review aims to evaluate the prevalence and implications of intimal and medial arterial calcification in peripheral arterial disease.

Intimal and medial arterial calcification in peripheral arterial disease a systematic review and meta-analysis of imaging and histological evidence

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This review aims to evaluate the prevalence and implications of intimal and medial arterial calcification in peripheral arterial disease.
Conducted a systematic review of imaging and histological evidence on arterial calcification in PAD.
Analyzed the prevalence of intimal and medial calcification in specified arterial regions.
Examined the association of calcification with patient characteristics.
Identified high prevalence of vascular calcification in PAD, especially in femoropopliteal and infra-popliteal regions.
Found significant associations between arterial calcification and distinct clinical characteristics.
Noted the lack of segment-matched CT-histology validation which limits conclusions.

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Systematic review reveals vascular calcification's role in peripheral arterial disease, implying complex patient characteristics.

BONTINIS et al. (2026) studied this question.

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