An optical fibre sensor detects FKBP12 binding protein, indicating potential applications in biomolecular sensing.
An optical fibre sensor with a long period grating (LPG) is described for the binding protein FKBP12 detection. An ad-hoc synthesized recognition element is immobilised on the fibre surface in correspondence of the LPG by using a home-made microfluidic flow-cell. Measurement is performed by flowing solutions in the flow-cell with increasing FKBP12 concentration and measuring the shift of the LPG resonant peak.
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Baldini et al. (2025) studied this question.
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