Fungicidal efficacy of caprylic acid using three different bovine milk types against Candida albicans: An in vitro study

Background: The success of endodontic therapy depends on thorough biomechanical preparation and the use of effective intracanal irrigants to achieve a microbe-free canal before obturation. Candida albicans is the most commonly isolated fungus from infected root canals and has a strong dentin affinity. Owing to its resistance to several intracanal medicaments, including calcium hydroxide, alternative antifungal agents are required. Bovine milk, which contains caprylic acid – a medium-chain fatty acid with known antimicrobial properties, may provide a natural and biocompatible adjunct for root canal disinfection. Aim: To evaluate the fungicidal effect of bovine milk containing caprylic acid using three different milk sources against C. albicans . Objectives: To compare the antifungal efficacy of caprylic acid in goat, cow, and buffalo milk using the disc-diffusion method. Materials and Methods: Different bovine milks were tested for antifungal activity against C. albicans by the standard disc-diffusion method. Zones of inhibition were measured in millimetres. Statistical Analysis: Chi-square and paired t-tests were applied. Results: Goat milk produced the widest inhibition zone, followed by buffalo and cow milk, demonstrating significant differences ( P < 0.001). Conclusion: Caprylic acid, derived from bovine milk, can serve as a natural, biocompatible alternative to existing intracanal irrigants to control fungal infections during endodontic therapy.