ABSTRACT Background mental: Δ R 2 = 0.016, p = 0.020), but not with PBC (physical: Δ R 2 = 0.008, p = 0.081; mental: Δ R 2 = 0.001, p = 0.609). Physical HRQOL was associated with higher age and fatigue, while mental HRQOL was associated with lower age, fatigue, and depression severity. Conclusions Patients with variant syndromes of autoimmune liver diseases show high physical and mental burden, with fatigue as the main contributor. Particularly PSC‐AIH goes along with more severely reduced HRQOL compared to the cholestatic liver disease alone, which is attributable to a higher symptom burden.
Uhlenbusch et al. (2026) studied this question.