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April 17, 2026JHEP ReportsOpen Access

Fatigue, depression, and impaired health-related quality of life in patients with vascular liver diseases: A multicentric European study

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Why the study?

Patient-reported outcomes are scarce in vascular liver diseases, including portal vein thrombosis and Budd-Chiari syndrome.

Population

488 respondents with portal vein thrombosis or Budd-Chiari syndrome across France, Spain, and Switzerland

Comparison

Comparisons with the general population

Design

Multicentre cross-sectional study

Authors

CRClémence RamierVHVirginia Hernandez-GeaLELaure Elkrief

Discussion

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Member takes

Overview

Should not yet change VLD care; leaves open causal effects of socioeconomic factors and anticoagulation on PROs.

Structured PICO

P
Population
488 patients with vascular liver diseases (portal vein thrombosis or Budd-Chiari syndrome) out of 1,136 eligible patients
C
Comparator
French and Spanish general populations
O
Outcome
Health-related quality of life (EQ-5D-5L), fatigue (MFIS-5), and depressive symptoms (PHQ-8)patient reported

Patients with vascular liver diseases experience a significant disease burden, with impaired health-related quality of life and high rates of fatigue and depressive symptoms compared to the general population.

Cite This Study

Ramier et al. (2026) studied this question.

synapsesocial.com/papers/6a7eb4d3ec6d7e203fcda3cahttps://doi.org/10.1016/j.jhepr.2026.101861
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fatigue, depression, and impaired health-related quality of life in patients with vascular liver diseases: a multicentric European study.2026
  2. 2For Me, Quality of Life Is When I Get Through the Day Without Thinking: I Won't Make It: A Participatory Qualitative Study of Health‐Related Quality of Life in Rare Liver Diseases2026 · 1 citations
  3. 3Association of fatigue and psychological distress with quality of life in patients with a previous venous thromboembolic event2009 · 45 citations
  4. 4Challenges in the care of rare vascular liver diseases: Insights from patients, health care providers, and patient organizations.2026
  5. 5Quality of Life in Patients With Variant Syndromes of Autoimmune Liver Diseases—A Cross‐Sectional Multicentre Study2026 · 3 citations