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February 5, 2026Journal of General VirologyOpen Access

Geographical and temporal trends of HIV-1 subtypes and drug resistance in China: a nationwide study over two decades (2003–2024)

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Authors

BXBin XieCentral South UniversityZWZhenggang WangCentral South UniversityQSQixiang SongCentral South University

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Implication

A nationwide analysis characterizes HIV-1 subtype trends and drug resistance patterns in China, suggesting urgent need for personalized treatment.

Key Points

  • This study aims to examine the trends of HIV-1 subtypes and drug resistance patterns in China over two decades.
  • Analyzed HIV-1 sequences from 81,563 individuals in China from 2003 to 2024.
  • Classified subtypes and CRFs using COMET V2.4.
  • Assessed transmitted drug resistance in 41,486 treatment-naïve individuals with the Stanford HIVdb program.
  • CRF01_AE was the most prevalent strain at 43.9%, with notable provincial variations.
  • Elevated resistance to non-nucleoside reverse transcriptase inhibitors observed in several provinces, exceeding 12%.
  • TDR rates for frequently prescribed regimens notably surpassed 5%, indicating urgent need for personalized therapy.

Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/69843451f1d9ada3c1fb2486https://doi.org/10.1099/jgv.0.002217
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