Demonstrates lipoxin B4 reduces gliosis in Müller cells, highlighting a potential neuroprotective strategy.
Müller glia are a significant source of LXB4 in the retina. This neuroprotective Müller glia pathway is amplified during chronic TRPV4 activation to counter-regulate gliosis. These findings support the targeting of the TRPV4-lipoxin pathway as a potential approach to protect against ocular hypertension-induced neurodegeneration in glaucoma.
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Kumar et al. (2026) studied this question.
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