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March 19, 2024Open Access

Regulation of Diseases-Associated Microglia in the Optic Nerve by Lipoxin B₄and Ocular Hypertension

Shubham Maurya Maggie Lin Shruthi Karnam Tanirika Singh Matangi Kumar Emily Ward Jeremy M. Sivak John G. Flanagan Karsten Gronert

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Abstract

The resident astrocyte-retinal ganglion cell (RGC) lipoxin circuit is impaired during retinal stress, which includes ocular hypertension-induced neuropathy. Lipoxin B

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Maurya et al. (2024) studied this question.

synapsesocial.com/papers/68e7362fb6db6435876b01a7 https://doi.org/10.1101/2024.03.18.585452

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1Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension2024 · 14 citations
2Lipoxin B<sub>4</sub> Mitigates TRPV4-Activated Muller Cell Gliosis During Ocular Hypertension2025
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4Downregulation of LOX Overexpression Promotes Retinal Ganglion Cells Survival in an Acute Ocular Hypertension Model2024
5Microglia Depletion leads to Increased Susceptibility to Ocular Hypertension-Dependent Glaucoma2024 · 2 citations