Key result
Bibliometric analysis identifies US leadership and highlights PCSK9, lipid peroxidation, and sex differences as hotspots.
This bibliometric analysis highlights the growing research focus on precision lipid management, PCSK9 inhibitors, and molecular mechanisms in coronary heart disease over the past decade.
Objective The incidence of coronary heart disease (CHD) is progressively increasing on an annual basis. Dyslipidemia constitutes a significant pathogenic factor in CHD, exerting a substantial influence on its onset and progression. Consequently, precise and effective lipid management is crucial for the prevention and cure of CHD. This study aims to examine the risk factors, therapeutic approaches, current research status and emerging trends in lipid management related to CHD. Method We searched for publications on lipid management of coronary heart disease from 01/01/2014 to 12/31/2023 in Web of Science and performed bibliometrics using CiteSpace, VOSviewer, Scimago Graphica, Gephi and R Studio. Results A total of 6,027 related articles were retrieved from the Web of Science database. After screening, 5,954 articles were included. Journal of Clinical Lipidology and Atherosclerosis were the journals with the most publications and citations, respectively. In this discipline, the United States has the largest number of publications, research institutions, citations, and collaborative partnerships. The burst keywords include sex difference, heterozygote familial hypercholesterolemia, PCSK9, lipid peroxidation, fish oil, monoclonal antibody, insulin sensitivity, and gene, etc. Conclusion Research on CHD indicates that risk factors influencing lipid levels encompass sex, genetics, PCSK9, and lipid peroxidation. There has been a growing trend in investigating the underlying mechanisms of these factors. Recent research hotspots have concentrated on disease prevention, prognosis, specific treatments for CHD, the development of new pharmaceuticals, and the molecular mechanisms of action. Future research is likely to continue focusing on more precise treatment protocols and the exploration of novel mechanisms.
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Liu et al. (2026) conducted a review in Coronary heart disease (n=5,954). Lipid management was evaluated on Bibliometric trends and hotspots. A bibliometric analysis of 5,954 articles from 2014 to 2023 identified the United States as the leading contributor and highlighted PCSK9, lipid peroxidation, and sex differences as research hotspots.
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