What question did this study set out to answer?

The study aims to investigate the sex differences in ΔFosB and FosB expression in the medullary dorsal horn during orofacial neuropathic pain development.

February 5, 2026Journal of Neuroscience Research

Sex Differences in Markers of Neuronal Adaptation in the Medullary Dorsal Horn During the Development of Orofacial Neuropathic Pain

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Authors

HLH. K. LimThe University of Sydney JKJames W. M. KangThe University of Sydney LHLuke A. HendersonThe University of Sydney

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Investigates sex differences in neuronal markers during orofacial neuropathic pain, highlighting implications for treatment.

Key Points

The study aims to investigate the sex differences in ΔFosB and FosB expression in the medullary dorsal horn during orofacial neuropathic pain development.
Analyzed immunoreactive cells of ΔFosB and FosB after infraorbital nerve chronic constriction injury (ION‐CCI) in rats.
Examined three post-injury phases: early (2 days), transitional (7–14 days), and late (28+ days).
Compared levels of both markers in male and female rats.
Male rats showed a significant decrease in ΔFosB from early to transitional phases, while females had lower levels consistently.
Females exhibited increased FosB expression during the early phase.
By the late phase, males had significantly higher ΔFosB expression in the superficial laminae compared to females.

Cite This Study

Lim et al. (2026) studied this question.

synapsesocial.com/papers/6984346ff1d9ada3c1fb2828 https://doi.org/10.1002/jnr.70117

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Sex Differences in Markers of Neuronal Adaptation in the Medullary Dorsal Horn During the Development of Orofacial Neuropathic Pain

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Implication

Key Points

Cite This Study

Sex Differences in Markers of Neuronal Adaptation in the Medullary Dorsal Horn During the Development of Orofacial Neuropathic Pain

Discussion

Member takes

Implication

Key Points

Cite This Study

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