What question did this study set out to answer?

To explore the bioactive peptides derived from sheep milk proteins using in-silico methods.

February 5, 2026

Revealing the Potential of Bioactive Peptides from Sheep Milk Casein and Whey: An In-silico Exploration

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In-silico analysis uncovers bioactive peptides in sheep milk proteins, indicating potential health benefits.

To explore the bioactive peptides derived from sheep milk proteins using in-silico methods.
Conducted in-silico analysis of α-lactalbumin, β-lactalbumin, and β-lactoglobulin 1/B.
Retrieved protein sequences from the UniProtKB database.
Analyzed amino acid composition and bioactive peptides formed after hydrolysis with pepsin and trypsin.
Used bioinformatics tools to assess physicochemical properties, bioactivity, and allergenicity.
Identified peptides with antimicrobial, antioxidant, antihypertensive, and immunomodulatory activities.
Found inhibition activity against dipeptidyl peptidase IV, relevant for type 2 diabetes management.
Predicted varying allergenicity, with some peptides being flagged as allergens due to sequence similarities.

Sathika et al. (2025) studied this question.

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