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Assess the effect of Annona muricata L. leaf extract on neuronal count in the temporal lobe of adult Wistar rats exposed to noise.

February 5, 2026

Leaf Extract Affects the Number of Neurons in the Temporal Lobe of Adult Wistar Rats Exposed to Noise

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Assess the effect of Annona muricata L. leaf extract on neuronal count in the temporal lobe of adult Wistar rats exposed to noise.
Used a posttest-only control group design with treatment and control groups.
Thirty male Wistar rats were exposed to 95 dB noise for 4 hours daily for 14 days.
Treatment group received Annona muricata L. leaf extract during the exposure period.
Neuronal counts were histologically determined and compared using an independent t-test.
Treatment group showed significantly higher neuronal numbers in the temporal lobe compared to control (p = 0.003).
Findings suggest that Annona muricata L. leaf extract provides neuroprotection against oxidative damage from noise exposure.

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Demonstrates increased neuronal numbers in adult Wistar rats exposed to noise, suggesting neuroprotective effects of Annona muricata leaf extract.

Astini et al. (2025) studied this question.

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Demonstrates increased neuronal numbers in adult Wistar rats exposed to noise, suggesting neuroprotective effects of Annona muricata leaf extract.