Catalyst-controlled divergent synthesis of 2,8dioxabicyclo[3.3.1]nonanes and benzo[ c ]chromen-6-ones

Oxabicyclic scaffolds are increasingly coveted for their distinctive bioactivities. Herein, we report a BF₃⦁OEt₂-catalyzed Michael addition/ketalization sequence to access structurally fascinating 2,8-dioxabicyclo[3.3.1]nonanes from easily accessible 4-hydroxy-6-methyl-2 H -pyran-2-one and ortho -hydroxychalcones. Simply by...