Key result
The COVID-19 pandemic period was associated with a non-significant increase in pericardiocentesis cases (92 vs 65; p=0.0796) and in-hospital mortality (14.4% vs 7.7%; p=0.22).
Why the study?
SARS-CoV-2 infection, late complications, and vaccines cause pericardial effusion, but the influence of the COVID-19 outbreak on pericardiocentesis trends was unclear.
Does the COVID-19 pandemic period influence the frequency of pericardiocentesis and patient mortality compared to the pre-pandemic period?
Observational (n=157)
No
Does the COVID-19 pandemic period influence the frequency of pericardiocentesis and patient mortality compared to the pre-pandemic period?
Absolute Event Rate: 14.4% vs 7.7%
p-value: p=0.22
The COVID-19 pandemic was associated with a non-significant increase in pericardiocentesis procedures, which the authors hypothesize may be driven by delayed care for chronic diseases rather than direct viral or vaccine effects.
Non-significant rises in pericardiocentesis and mortality during pandemic; hypothesis-generating for delayed care effects, needs prospective confirmation.
Background: SARS-CoV-2 infection, its late complications, and SARS-CoV-2 vaccines are known to cause pericardial effusion. We sought to investigate the influence of the COVID-19 outbreak on trends in pericardiocentesis. Methods: We performed a retrospective population study including all >18 years patients undergoing pericardiocentesis in a single tertiary hospital between January 2018 and April 2022. The effusion characteristics and patient outcomes were compared between patients admitted before and after the COVID-19 outbreak. Results: 92 patients underwent pericardiocentesis cases during the COVID-19 period compared to 65 patients during the pre-COVID-19 period (χ2 = 3.07, p = 0.0796). Only 15% of the post-COVID-19 outbreak cases were related to COVID-19 infection or vaccine. In-hospital mortality was numerically higher during the post-COVID-19 group (7.7% vs. 14.4%), but this difference did not reach statistical significance (p = 0.22). The 90-day mortality was also similar between groups. Conclusions: A numerical, yet statistically insignificant increase in pericardiocentesis was observed following the COVID-19 outbreak. We assume this observation cannot be attributed solely to the virus and vaccines per se. Neglect of other chronic diseases, social distancing, and widespread availability of point-of-care ultrasound may have contributed to this observation.
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Shabtay et al. (2026) conducted an observational in Pericardial effusion (n=157). Post-COVID-19 outbreak period vs. Pre-COVID-19 outbreak period was evaluated on In-hospital mortality (p=0.22). The COVID-19 pandemic period was associated with a non-significant increase in pericardiocentesis cases (92 vs 65; p=0.0796) and in-hospital mortality (14.4% vs 7.7%; p=0.22).
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