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The aim is to investigate how kisspeptin affects insulin resistance related to PCOS through specific signaling pathways.

February 5, 2026PLoS ONEOpen Access

Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway

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The aim is to investigate how kisspeptin affects insulin resistance related to PCOS through specific signaling pathways.
Established a PCOS-IR mouse model using DHEA and a high-fat diet.
Measured expressions of kisspeptin, PI3K, p-PI3K, AKT, p-AKT, and GLUT4 via various techniques.
Evaluated mitochondrial membrane potential and reactive oxygen species levels using flow cytometry.
Kisspeptin increased GLUT4 expression in granulosa cells by activating the PI3K/AKT pathway.
In vitro, kisspeptin lowered reactive oxygen species levels and improved mitochondrial function.

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Experimental research demonstrates kisspeptin improves insulin resistance in PCOS, suggesting new therapeutic avenues.

Sun et al. (2026) studied this question.

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