Case report shows lichen planopilaris exacerbation in a patient with metastatic melanoma after pembrolizumab treatment, suggesting need for tailored care.
Key Points
To report a case of lichen planopilaris exacerbation triggered by pembrolizumab in a melanoma patient and discuss its management.
Observed a 75-year-old woman with stable lichen planopilaris during pembrolizumab treatment.
Assessed disease progression despite treatments with hydroxychloroquine and topical clobetasol.
Introduced oral doxycycline and monitored outcomes over ten months.
Disease activity progressed during treatment but stabilized after adjunctive therapy.
Areas of scarring alopecia persisted despite stabilization.
Causality assessment using the Naranjo Algorithm indicated a probable drug reaction.