Lung Physiologically Based Pharmacokinetic Modelling to Predict Sublingual Buprenorphine Kinetics Following Oral Inhalation

TOBECHI BRENDAN NNANNA; Daniel Okwudili  Okwudili Nnamani; Elias Bestman Adikwu; Chisom Anthony Nnanna

doi:10.1039/d5pm00266d

January 1, 2026RSC PharmaceuticsOpen Access

Lung Physiologically Based Pharmacokinetic Modelling to Predict Sublingual Buprenorphine Kinetics Following Oral Inhalation

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Key Points

This research aims to model the pharmacokinetics of buprenorphine via the pulmonary system using unique inhalation methods.
Developed a physiological based pharmacokinetic model for lung administration.
Assessed buprenorphine uptake through oral inhalation techniques.
Analyzed the pharmacokinetics of buprenorphine in a diverse pulmonary interface.
The model successfully predicts buprenorphine absorption patterns post-inhalation.
Findings indicate enhanced efficiency in drug uptake through the pulmonary route.

Implication

Investigative modelling predicts buprenorphine kinetics in the pulmonary system, suggesting new pharmacological approaches.

Abstract

The pulmonary system embodies a heterogeneous yet highly efficient interface for xenobiotic uptake, offering unique translational opportunities for pharmacokinetic modelling. In this study, an investigation was conducted to assess the...

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Cite This Study

NNANNA et al. (2026) studied this question.

synapsesocial.com/papers/69843543f1d9ada3c1fb3efb https://doi.org/10.1039/d5pm00266d

View Full Paper

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Lung Physiologically Based Pharmacokinetic Modelling to Predict Sublingual Buprenorphine Kinetics Following Oral Inhalation

Key Points

Implication

Abstract

Discussion

Cite This Study

Lung Physiologically Based Pharmacokinetic Modelling to Predict Sublingual Buprenorphine Kinetics Following Oral Inhalation

Key Points

Implication

Abstract

Discussion

Cite This Study

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