Lung Physiologically Based Pharmacokinetic Modelling to Predict Sublingual Buprenorphine Kinetics Following Oral Inhalation

Key Points

• This research aims to model the pharmacokinetics of buprenorphine via the pulmonary system using unique inhalation methods.
• Developed a physiological based pharmacokinetic model for lung administration.
• Assessed buprenorphine uptake through oral inhalation techniques.
• Analyzed the pharmacokinetics of buprenorphine in a diverse pulmonary interface.
• The model successfully predicts buprenorphine absorption patterns post-inhalation.
• Findings indicate enhanced efficiency in drug uptake through the pulmonary route.