Comparing High-Grade Non-Rhabdomyosarcoma Soft-Tissue Sarcoma in Adult and Paediatric Populations

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This research aims to compare treatment approaches and outcomes of high-grade soft tissue sarcoma in adult and pediatric patients.
Review of 414 patient records (383 adults, 31 children) with high-grade non-rhabdomyosarcoma STS.
Analysis of age at diagnosis, follow-up duration, tumor size, and rates of metastatic disease.
Comparison of treatment modalities used, such as pre-operative radiation and post-operative chemotherapy.
Mean tumor size was similar between adults (9 cm) and children (8 cm).
Pre-operative radiation therapy was more common in adults (83%) compared to children (45%).
Similar local recurrence-free survival (LRFS) and metastatic disease-free survival (MDFS) rates were observed.
Overall survival (OS) was greater in the pediatric cohort.

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Compares oncologic outcomes of high-grade soft tissue sarcoma in adults and children, suggesting treatment differences impact survival.

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Sullivan et al. (2026) studied this question.

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