Soft-tissue sarcomas of the extremities in patients of pediatric age
Key result
Multimodality treatment of pediatric soft-tissue sarcomas of the extremities resulted in a 5-year event-free survival of 37.1% for rhabdomyosarcoma and 72.6% for non-rhabdomyosarcoma.
Population
204 pediatric patients with soft-tissue sarcomas of the limbs treated between 1977 and 2006, including 52…
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
Limb STS outcomes vary sharply by histology in children; Level 5 series leaves open optimal multimodality strategies for high-risk RMS.
Study Design
Type
Observational (n=204)
Multicenter
No
Structured PICO
P
Population
204 children and adolescents with soft-tissue sarcomas of the extremities treated with a multimodality approach between 1977 and 2006.
E
Exposure
Multimodality approach including surgery, chemotherapy, and radiotherapy
O
Outcome
5-year event-free survival (EFS)hard clinical
Extremity rhabdomyosarcoma in pediatric patients has a poor prognosis compared to non-rhabdomyosarcoma soft-tissue sarcomas, highlighting the need for multidisciplinary treatment.
Cite This Study
Casanova et al. (2007) conducted an observational in Soft-tissue sarcomas of the extremities (n=204). Multimodality treatment (surgery, chemotherapy, radiotherapy) was evaluated on 5-year event-free survival (EFS). Multimodality treatment of pediatric soft-tissue sarcomas of the extremities resulted in a 5-year event-free survival of 37.1% for rhabdomyosarcoma and 72.6% for non-rhabdomyosarcoma.