What question did this study set out to answer?

This research aims to synthesize and evaluate the antiviral efficacy of novel thiosemicarbazones against various DNA and RNA viruses.

February 5, 2026Chemical Biology & Drug Design

From Synthesis to Efficacy: Synthesis, Structural Analysis, and Antiviral Activity of 5‐(Trifluoromethoxy)‐ 1 H ‐indole‐2,3‐dione 3‐Thiosemicarbazones

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Authors

ÖSÖzge Soylu‐EterIstanbul University LPLeentje PersoonsRega Institute for Medical Research LNLieve NaesensRega Institute for Medical Research

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Implication

In vitro experiments demonstrate antiviral efficacy of synthesized compounds in human lung fibroblasts, suggesting potential for broader antiviral development.

Key Points

This research aims to synthesize and evaluate the antiviral efficacy of novel thiosemicarbazones against various DNA and RNA viruses.
Synthesis of 5‐(trifluoromethoxy)‐1H‐indole‐2,3‐dione thiosemicarbazones with methyl or ethyl substitutions.
Conducted cytopathic effect (CPE) reduction assays on synthesized compounds using human embryonic lung fibroblast cells.
Compared antiviral activity and cytotoxicity of compounds with differing substituents, particularly at positions 1 and 4 of the phenyl ring.
Ethyl-substituted thiosemicarbazones demonstrated higher antiviral activity and lower cytotoxicity compared to methyl-substituted analogues.
Average EC50 values for select compounds ranged from 1.6 to 6.6 μM against HSV-1, HSV-2, and vaccinia virus.
Trifluoromethyl analogue showed suppression of human adenovirus type 2 and coronavirus HCoV-229E.

Cite This Study

Soylu‐Eter et al. (2026) studied this question.

synapsesocial.com/papers/6984359ef1d9ada3c1fb4969 https://doi.org/10.1111/cbdd.70259

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Implication

In vitro experiments demonstrate antiviral efficacy of synthesized compounds in human lung fibroblasts, suggesting potential for broader antiviral development.

From Synthesis to Efficacy: Synthesis, Structural Analysis, and Antiviral Activity of 5‐(Trifluoromethoxy)‐ 1 H ‐indole‐2,3‐dione 3‐Thiosemicarbazones

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Cite This Study

From Synthesis to Efficacy: Synthesis, Structural Analysis, and Antiviral Activity of 5‐(Trifluoromethoxy)‐ 1 H ‐indole‐2,3‐dione 3‐Thiosemicarbazones

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Cite This Study

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