What question did this study set out to answer?

This research aims to evaluate the mortality burden of rare diseases in Argentina from 1997 to 2017 and analyze its trends and spatial distribution.

February 5, 2026Journal of Rare DiseasesOpen Access

Epidemiology of rare disease mortality in Argentina (1997–2017)

View Full Paper

Ask AI

Bookmark

Authors

Epidemiological analysis reveals rare disease mortality trends in Argentina, highlighting regional disparities.

This research aims to evaluate the mortality burden of rare diseases in Argentina from 1997 to 2017 and analyze its trends and spatial distribution.
Analyzed Death Certificates from the Ministry of Health using ICD-10 classifications.
Used a Python web scraper for a correspondence between Orpha and ICD-10 codes.
Calculated the rare diseases mortality rate per 1,000 deaths by sex, age groups, and ICD-10 chapters across five regions of Argentina.
Employed Joinpoint software for secular trend analysis and Moran’s and LISA indices for spatial assessment.
The overall rare disease mortality rate was 189.4 deaths per 1,000.
Patagonia had the highest mortality rate, followed by Cuyo, Centro, Northeast, and Northwest regions, with higher rates in women.
Observations indicated a negative secular trend from 1997 to 2009, transitioning to a positive trend from 2009 to 2017.
Geographical clustering showed high rates predominantly in central Argentina and low rates in the northern regions.
The prevalent causes of death categorized by ICD-10 included neoplasms, eye diseases, and congenital malformations.

Morales et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark