Predictors of Severe Outcomes in COVID-19: Evidence from Real-World Multicenter Retrospective Study (2020–2024)

Małgorzata Wajdowicz; Krystyna Dobrowolska; Kinga Brzdęk; Jakub Janczura; Krzysztof Simon; Łukasz Supronowicz; Piotr Rzymski; Magdalena Rogalska; Piotr Czupryna; Krzysztof Tomasiewicz; Marcin Hawro; Michał Brzdęk

doi:10.3390/jcm15031207

February 3, 2026Journal of Clinical MedicineOpen Access

Predictors of Severe Outcomes in COVID-19: Evidence from Real-World Multicenter Retrospective Study (2020–2024)

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Key Points

To assess sex-related differences in clinical outcomes and identify predictors of mortality and mechanical ventilation in hospitalized COVID-19 patients.
Analyzed demographic, clinical, laboratory, and outcome data from 2811 hospitalized patients.
Performed a retrospective cohort study across four infectious disease centers in eastern Poland.
Utilized multivariable logistic regression to identify predictors of mortality and mechanical ventilation.
Women were older and had more comorbidities compared to men, but overall mortality did not differ by sex.
Men required more oxygen therapy and had more severe respiratory conditions.
Independent mortality predictors included age ≥ 80, procalcitonin > 1 ng/mL, IL-6 > 100 pg/mL, and oxygen therapy at admission.

Implication

This retrospective cohort study identifies factors predicting mortality and mechanical ventilation in hospitalized COVID-19 patients, suggesting areas for focused treatment.

Discussion

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Cite This Study

Wajdowicz et al. (2026) studied this question.

synapsesocial.com/papers/698435fff1d9ada3c1fb56cd https://doi.org/10.3390/jcm15031207

View Full Paper

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Predictors of Severe Outcomes in COVID-19: Evidence from Real-World Multicenter Retrospective Study (2020–2024)

Key Points

Implication

Discussion

Cite This Study

Predictors of Severe Outcomes in COVID-19: Evidence from Real-World Multicenter Retrospective Study (2020–2024)

Key Points

Implication

Discussion

Cite This Study

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