Key result
Intact BDNF/TrkB signaling drives normal cardiac contraction and relaxation via enhanced Ca2+ cycling.
Why the study?
Does BDNF/TrkB signaling regulate cardiac contraction and relaxation?
Population
Preclinical models of cardiac muscle physiology
Design
Preclinical
Authors
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May identify new autonomic target in cardiac dysfunction; animal data leave open human translation and therapeutic relevance.
Does BDNF/TrkB signaling regulate cardiac contraction and relaxation?
Constitutive BDNF/TrkB signaling regulates cardiac contraction and relaxation via CaMKII-dependent modulation of calcium cycling, representing a novel mechanism of peripheral nervous system control over cardiac physiology.
Feng et al. (2015) studied this question. Intact BDNF/TrkB signaling is essential for normal cardiac contraction and relaxation, independently enhancing myocardial performance via Ca2+ cycling.
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