Key result
BDNF deficiency impairs survival of endothelial cells in intramyocardial vessels leading to hemorrhage and death, while BDNF overexpression increases capillary density in mouse hearts.
Why the study?
Does BDNF play a role in maintaining intramyocardial vessel stability and endothelial cell survival in mice?
Does BDNF play a role in maintaining intramyocardial vessel stability and endothelial cell survival in mice?
BDNF is essential for maintaining vessel stability in the heart through direct angiogenic actions on endothelial cells.
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BDNF supports vessel stability in mouse hearts; leaves open translation to human cardiac angiogenesis or therapy.
Donovan et al. (2000) studied Intramyocardial vessel stabilization. BDNF deficiency and ectopic BDNF overexpression vs. Wild-type/endogenous BDNF expression was evaluated on Endothelial cell survival, apoptosis, and capillary density. BDNF deficiency impairs survival of endothelial cells in intramyocardial vessels leading to hemorrhage and death, while BDNF overexpression increases capillary density in mouse hearts.
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