Key result
Increasing coronary artery calcium was associated with a higher incidence of dementia, with an odds ratio of 2.43 (95% CI 1.39-4.22) in the highest quartile compared to the lowest quartile.
Why the study?
Does higher coronary artery calcification correlate with poorer cognitive function and dementia in older adults?
Population
Men and women born 1907 to 1935 from the AGES-Reykjavik Study cohort (n=4250 with complete data)
Comparison
Higher coronary artery calcification measured… vs Lower coronary artery calcification (CAC)
Design
Cross-sectional
Authors
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Highlights a potential heart-brain link where severe coronary calcification signals cognitive risk; leaves open whether aggressive.
Cross-Sectional (n=4,250)
Does higher coronary artery calcification correlate with poorer cognitive function and dementia in older adults?
Effect estimate: OR 2.43 (95% CI 1.39-4.22)
Absolute Event Rate: 38.8% vs 10.3%
p-value: p=0.002
Increasing atherosclerotic load assessed by coronary artery calcium is associated with poorer cognitive performance and dementia, and these relations are mediated by evidence of brain pathology.
Vidal et al. (2010) conducted a cross-sectional in coronary artery disease (n=4,250). Coronary Artery Calcium (CAC) measurement was evaluated on association of coronary artery calcium with dementia incidence (OR 2.43, 95% CI 1.39-4.22, p=0.002). Increasing coronary artery calcium was associated with a higher incidence of dementia, with an odds ratio of 2.43 (95% CI 1.39-4.22) in the highest quartile compared to the lowest quartile.
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